Loss of vexed function results in excessive activation of the innate immune response in the brain, leading to loss of DA neurons. We demonstrate that vexed is specifically required within cortex glia to maintain neuronal viability. Based on this phenotype, we refer to CG42339 as vexed. CG42339 mutants display a progressive loss of DA neurons and locomotor dysfunction, along with an accumulation of advanced glycation end products (AGEs) in the brain. Here we describe the role of a previously uncharacterized gene, CG42339, in the loss of DA neurons using Drosophila Melanogaster. We previously completed a screen identifying genes associated with the progressive degeneration of DA neurons. However, little is known about why DA neurons are selectively vulnerable to PD. The hallmark of Parkinson’s disease (PD) is the loss of dopaminergic (DA) neurons in the brain.
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